The fastest-growing and largest of the 41 sized OTC & Nutraceuticals markets in North America, 2023 to 2033, with active clinical trials.
| # | Market | 2023 | 2033 (projected) | CAGR | Active trials |
|---|---|---|---|---|---|
| 1 | Cannabidiol (CBD) Supplements | $2.7 Bn | $11.5 Bn | 15.8% | 150 |
| 2 | Prebiotics | $4.1 Bn | $11.3 Bn | 10.8% | 97 |
| 3 | Beauty Supplements | $2.1 Bn | $4.5 Bn | 8.2% | 117 |
| 4 | Coenzyme Q10 | $250 Mn | $540 Mn | 8% | 23 |
| 5 | Adaptogens | $4.1 Bn | $8.3 Bn | 7.5% | 14 |
| 6 | Mood and Stress Supplements | $5.3 Bn | $10.4 Bn | 7.1% | 68 |
| 7 | Plant-Based Supplements | $6.2 Bn | $12.1 Bn | 7% | 41 |
| 8 | Sports Nutrition | $26 Bn | $50.7 Bn | 6.9% | 52 |
| 9 | Herbal Supplements | $41 Bn | $77.7 Bn | 6.6% | 38 |
| 10 | Omega 3 Fatty Acid | $2.1 Bn | $3.8 Bn | 6.4% | 162 |
| # | Market | 2023 | 2033 (projected) | CAGR | Active trials |
|---|---|---|---|---|---|
| 1 | Nutritional Supplements | $192.5 Bn | $338.3 Bn | 5.8% | 1,043 |
| 2 | Dietary Supplements | $154 Bn | $255.7 Bn | 5.2% | 1,217 |
| 3 | Functional Food | $142.5 Bn | $248.1 Bn | 5.7% | 866 |
| 4 | Over The Counter (OTC) Drugs | $89 Bn | $128 Bn | 3.7% | 163 |
| 5 | Over The Counter (OTC) Pharmaceuticals | $89 Bn | $128 Bn | 3.7% | 163 |
| 6 | Over The Counter (OTC) Consumer | $75.5 Bn | $113.9 Bn | 4.2% | 163 |
| 7 | Herbal Supplements | $41 Bn | $77.7 Bn | 6.6% | 38 |
| 8 | Sports Nutrition | $26 Bn | $50.7 Bn | 6.9% | 52 |
| 9 | Over The Counter (OTC) Vitamins and Minerals | $16 Bn | $24.8 Bn | 4.5% | 160 |
| 10 | Clinical Nutrition | $14.3 Bn | $25.8 Bn | 6.1% | 207 |
2033 values are projected from the 2023 size and the CAGR. Each market name opens its report. Active trials: recruiting, about to start or running, in US, Canada.
Cannabidiol (CBD) Supplements grows fastest, at 15.8% a year from 2023 to 2033, ahead of Prebiotics (10.8%).
Nutritional Supplements is the largest, worth about $192.5 Bn in 2023 and $338.3 Bn by 2033 (projected).
Sources: market size and growth: Acuitas Health Analytics research (2023 base year, forecasts to 2033). Trials: ClinicalTrials.gov (fetched 10 Nov 2026); found by search words, so counts are a guide.