Mental health Drugs: Medicare Part D Spending

• 54medicines with Part D spending (calendar year 2024)

Each number has its full source under its own list below.

1. 1Duloxetine HClDuloxetine HCl · $0.35 per unit$308.8 million
2. 2Escitalopram OxalateEscitalopram Oxalate · $0.19 per unit$141 million
3. 3Venlafaxine HCl ERVenlafaxine HCl · $0.35 per unit$118.5 million
4. 4Buspirone HClBuspirone HCl · $0.15 per unit$111.2 million
5. 5Hydroxyzine HCl*Hydroxyzine HCl · $0.21 per unit$73.9 million
6. 6Doxepin HCl*Doxepin HCl · $0.92 per unit$65.7 million
7. 7AlprazolamAlprazolam · $0.09 per unit$60.7 million
8. 8Amitriptyline HClAmitriptyline HCl · $0.22 per unit$54.7 million
9. 9Lorazepam*Lorazepam · $0.14 per unit$52.4 million
10. 10Citalopram HBrCitalopram Hydrobromide · $0.12 per unit$48.6 million
11. 11Paroxetine HClParoxetine HCl · $0.21 per unit$45.6 million
12. 12ValtocoDiazepam · $354.13 per unit$24.4 million
13. 13Effexor XRVenlafaxine HCl · $18.84 per unit$23.8 million
14. 14Ativan*Lorazepam · $40.05 per unit$22.6 million
15. 15Nortriptyline HClNortriptyline HCl · $0.19 per unit$20 million

Source: Centers for Medicare & Medicaid Services, Medicare Part D Spending by Drug, calendar year 2024. Retrieved 12 Nov 2026.

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