Pain Drugs: Medicare Part D Spending

• 99medicines with Part D spending (calendar year 2024)

Each number has its full source under its own list below.

1. 1Hydrocodone-AcetaminophenHydrocodone/Acetaminophen · $0.28 per unit$387 million
2. 2Diclofenac Sodium*Diclofenac Sodium · $0.41 per unit$341.8 million
3. 3OxycontinOxycodone HCl · $11.30 per unit$337.8 million
4. 4Oxycodone-AcetaminophenOxycodone HCl/Acetaminophen · $0.33 per unit$243.3 million
5. 5Xtampza EROxycodone Myristate · $11.04 per unit$232.8 million
6. 6Buprenorphine-NaloxoneBuprenorphine HCl/Naloxone HCl · $2.63 per unit$199.7 million
7. 7PregabalinPregabalin · $0.31 per unit$199.2 million
8. 8Lupron DepotLeuprolide Acetate · $5,177.85 per unit$164 million
9. 9BelbucaBuprenorphine HCl · $12.76 per unit$160.1 million
10. 10LidocaineLidocaine · $2.25 per unit$160 million
11. 11Oxycodone HClOxycodone HCl · $0.20 per unit$132.8 million
12. 12Diclofenac EpolamineDiclofenac Epolamine · $10.75 per unit$112.4 million
13. 13BuprenorphineBuprenorphine · $61.65 per unit$112.3 million
14. 14Tramadol HClTramadol HCl · $0.11 per unit$88.1 million
15. 15VivitrolNaltrexone Microspheres · $1,621.97 per unit$73.1 million

Source: Centers for Medicare & Medicaid Services, Medicare Part D Spending by Drug, calendar year 2024. Retrieved 12 Nov 2026.

• Brain and nerves
• Bones and joints