Pain Medicines Approved in the EU (EMA)

• 36medicines authorised in the EU (authorised now)

Each number has its full source under its own list below.

• 17Jul2025

  Attrogy

  Active substance: diflunisal

  EMEA/H/C/006248
• 19Dec2024

  Buprenorphine Neuraxpharm

  Active substance: buprenorphine hydrochloride

  EMEA/H/C/006188
• 17Aug2022

  Rayvow

  Active substance: lasmiditan succinate

  EMEA/H/C/005332
• 24Jan2022

  Vyepti

  Active substance: Eptinezumab

  EMEA/H/C/005287
• 16Nov2020

  Exparel liposomal

  Active substance: bupivacaine

  EMEA/H/C/004586
• 18Feb2019

  Rizmoic

  Active substance: naldemedine tosilate

  EMEA/H/C/004256
• 20Nov2018

  Buvidal

  Active substance: buprenorphine

  EMEA/H/C/004651
• 14Nov2018

  Emgality

  Active substance: Galcanezumab

  EMEA/H/C/004648
• 26Jul2018

  Aimovig

  Active substance: erenumab

  EMEA/H/C/004447
• 25Jun2018

  Dzuveo

  Active substance: sufentanil citrate

  EMEA/H/C/004335
• 10Nov2017

  Zubsolv

  Active substance: buprenorphine hydrochloride;naloxone hydrochloride dihydrate

  EMEA/H/C/004407
• 9Nov2017

  Nyxoid

  Active substance: naloxone hydrochloride dihydrate

  EMEA/H/C/004325
• 2Jun2017

  Elmiron

  Active substance: pentosan polysulfate sodium

  EMEA/H/C/004246
• 11Jan2016

  Eptifibatide Accord

  Active substance: eptifibatide

  EMEA/H/C/004104
• 20Aug2015

  Duloxetine Zentiva

  Active substance: duloxetine

  EMEA/H/C/003935

Source: European Medicines Agency, Centrally authorised human medicines (EPAR), authorised now. Retrieved 12 Nov 2026.

• Brain and nerves
• OTC medicines
• Bones and joints